The Mayer Lab @ RuG
Repurposing natural designs for man-made innovations
PUBLICATIONS
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A strategy to select macrocyclic peptides featuring asymmetric molecular scaffolds as cyclization units by phage display
T.R. Oppewal, I.D. Jansen J. Hekelaar & C. Mayer*
Journal of the American Chemical Society, 144:3644-3652 (2022) → full text- featured in Nachrichten aus der Chemie
- A preprint of this manuscript is available on ChemRxiv
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Catalytic and structural properties of ATP-dependent caprolactamase from Pseudomonas jessenii
A. Marjanovic, H.J. Rozeboom, M.S. de Vries, C. Mayer*, M. Otzen, H.J. Wijma & D.B. Janssen*
Proteins: Structure, Function, and Bioinformatics, 89:1079-1098 (2021) → full text -
Opportunities for interfacing organometallic catalysts with cellular metabolism
R. Rubini & C. Mayer*
Book chapter in Comprehensive Organometallic Chemistry IV (2021) → full text -
Addicting Escherichia Coli to new-to-nature reactions
R. Rubini & C. Mayer*
ACS Chemical Biology, 15:3093-3098 (2020) → full text- featured in Medium.com
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Genetic-Code-Expansion Strategies for Vaccine Developmen
J.A. Fok & C. Mayer*
ChemBioChem, 21:3291–3300 (2020) → full text- Selected as Very Important Paper
- part of the Xenobiology special collection
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Chance emergence of catalytic activity and promiscuity in a self-replicator
J. Ottelé, A.S. Hussain, C. Mayer* & S. Otto*
Nature Catalysis, 3:547-553 (2020) → full text- Read a News & Views article and a Behind The Paper blog post in Nature Chemistry
- featured in C&EN and Phys.org
- Dutch summary for highschool students in C2W
- A preprint of this manuscript is available on ChemRxiv
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Affinity-selected bicyclic peptide G-quadruplex ligands mimic a protein-like binding mechanism
K.C. Liu, K. Röder, C. Mayer, S. Adhikari, D.J. Wales* & S. Balasubramanian*
Journal of the American Chemical Society, 142:8367-8373 (2020) → full text -
The importance of catalytic promiscuity for enzyme design and evolution
R.B. Leveson-Gower, C. Mayer* & G. Roelfes*
Nature Reviews Chemistry, 3:687-705 (2019) → full text -
A screening platform to identify and tailor biocompatible small-molecule catalysts
R. Rubini, I. Ivanov & C. Mayer*
Chemistry - A European Journal, 25:16017-16021 (2019) → full text -
Selection, addiction & catalysis: emerging trends for the incorporation of non-canonical amino acids into peptides and proteins in vivo
C. Mayer*
ChemBioChem, 20:1357–1364 (2019) → full text -
Directed evolution of a designer enzyme featuring an unnatural catalytic amino acid
C. Mayer*, C. Dulson, E. Reddem, A-M. W.H. Thunnissen & G. Roelfes*
Angewandte Chemie, 131:2105-2109 (2019) → full text- Selected as Hot Paper
- highlighted by ScienceDaily, ChemistryViews and Phys.org
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Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts.
B. Herdy, C. Mayer, D. Varshney, G. Marsico, P. Murat, C. Taylor, C. D'Santos, D. Tannahill & S. Balasubramanian*
Nucleic Acid Research , 46:11592-11604 (2018) → full text -
A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue.
I. Drienovská, C. Mayer, C. Dulson & J.G. Roelfes*
Nature Chemistry 10:946-952 (2018) → full text- highlighted by Phys.org and Chembites
- Dutch summary for highschool students by C2W
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G-quadruplex structures within the 3’-UTR of LINE-1 elements stimulate retrotransposition.
A.B. Sahakyan, P. Murat, C. Mayer & S. Balasubramanian*
Nature Structural & Molecular Biology 24:243-247 (2017) → full text -
An epigenetics-inspired DNA-based data storage system.
C. Mayer, G.R. McInroy, P. Murat, P. van Delft & S. Balasubramanian*
Angewandte Chemie 128:11310-11314 (2016) → full text- Selected as Hot Paper
- Featured in Nature Biotechnology: Computing: Nothing more than DNA
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Building proficient enzymes with foldamer prostheses.
C. Mayer, M.M. Müller, S.H. Gellman, & D. Hilvert*
Angewandte Chemie 126:7098-7101 (2016) → full text- Selected as Hot Paper
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Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase.
N. Preiswerk, T. Beck, J.D. Schulz, P. Milovnik, C. Mayer, J.B. Siegel, D. Baker & D. Hilvert*
Proceedings of the National Academy of Sciences 111:8013-8018 (2014) → full text -
A genetically encodable ligand for transfer hydrogenation.
C. Mayer & D. Hilvert
European Journal of Organic Chemistry 17:3427-3431 (2013) → full text -
An artificial metalloenzyme for olefin metathesis.
C. Mayer D.G. Gillingham, T.R. Ward & D. Hilvert*
Chemical Communications 47:12068-12070 (2011) → full text -
Synthesis of gamma-halogenated and long-chain ß-hydroxy-a-amino acids and 2-amino-1,3-diols using threonine aldolases.
J. Steinreiber, K. Fresko, C. Mayer, C. Reisinger, M. Schürmann & H. Griengl*
Tetrahedron 63:8088-8093 (2007) → full text