The Mayer Lab @ RuG

Repurposing natural designs for man-made innovations

PUBLICATIONS

1. A strategy to select macrocyclic peptides featuring asymmetric molecular scaffolds as cyclization units by phage display
   T.R. Oppewal, I.D. Jansen J. Hekelaar & C. Mayer*
   Journal of the American Chemical Society, 144:3644-3652 (2022) → full text

   • featured in Nachrichten aus der Chemie
   • A preprint of this manuscript is available on ChemRxiv
   

2. Catalytic and structural properties of ATP-dependent caprolactamase from Pseudomonas jessenii
   A. Marjanovic, H.J. Rozeboom, M.S. de Vries, C. Mayer*, M. Otzen, H.J. Wijma & D.B. Janssen*
   Proteins: Structure, Function, and Bioinformatics, 89:1079-1098 (2021) → full text

3. Opportunities for interfacing organometallic catalysts with cellular metabolism
   R. Rubini & C. Mayer*
   Book chapter in Comprehensive Organometallic Chemistry IV (2021) → full text

4. Addicting Escherichia Coli to new-to-nature reactions
   R. Rubini & C. Mayer*
   ACS Chemical Biology, 15:3093-3098 (2020) → full text

   • featured in Medium.com
   

5. Genetic-Code-Expansion Strategies for Vaccine Developmen
   J.A. Fok & C. Mayer*
   ChemBioChem, 21:3291–3300 (2020) → full text

   • Selected as Very Important Paper
   • part of the Xenobiology special collection
   

6. Chance emergence of catalytic activity and promiscuity in a self-replicator
   J. Ottelé, A.S. Hussain, C. Mayer* & S. Otto*
   Nature Catalysis, 3:547-553 (2020) → full text

   • Read a News & Views article and a Behind The Paper blog post in Nature Chemistry
   • featured in C&EN and Phys.org
   • Dutch summary for highschool students in C2W
   • A preprint of this manuscript is available on ChemRxiv
   

7. Affinity-selected bicyclic peptide G-quadruplex ligands mimic a protein-like binding mechanism
   K.C. Liu, K. Röder, C. Mayer, S. Adhikari, D.J. Wales* & S. Balasubramanian*
   Journal of the American Chemical Society, 142:8367-8373 (2020) → full text

8. The importance of catalytic promiscuity for enzyme design and evolution
   R.B. Leveson-Gower, C. Mayer* & G. Roelfes*
   Nature Reviews Chemistry, 3:687-705 (2019) → full text

9. A screening platform to identify and tailor biocompatible small-molecule catalysts
   R. Rubini, I. Ivanov & C. Mayer*
   Chemistry - A European Journal, 25:16017-16021 (2019) → full text

10. Selection, addiction & catalysis: emerging trends for the incorporation of non-canonical amino acids into peptides and proteins in vivo
    C. Mayer*
    ChemBioChem, 20:1357–1364 (2019) → full text

11. Directed evolution of a designer enzyme featuring an unnatural catalytic amino acid
    C. Mayer*, C. Dulson, E. Reddem, A-M. W.H. Thunnissen & G. Roelfes*
    Angewandte Chemie, 131:2105-2109 (2019) → full text

    • Selected as Hot Paper
    • highlighted by ScienceDaily, ChemistryViews and Phys.org
    

12. Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts.
    B. Herdy, C. Mayer, D. Varshney, G. Marsico, P. Murat, C. Taylor, C. D'Santos, D. Tannahill & S. Balasubramanian*
    Nucleic Acid Research , 46:11592-11604 (2018) → full text

13. A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue.
    I. Drienovská, C. Mayer, C. Dulson & J.G. Roelfes*
    Nature Chemistry 10:946-952 (2018) → full text

    • highlighted by Phys.org and Chembites
    • Dutch summary for highschool students by C2W

14. G-quadruplex structures within the 3’-UTR of LINE-1 elements stimulate retrotransposition.
    A.B. Sahakyan, P. Murat, C. Mayer & S. Balasubramanian*
    Nature Structural & Molecular Biology 24:243-247 (2017) → full text

15. An epigenetics-inspired DNA-based data storage system.
    C. Mayer, G.R. McInroy, P. Murat, P. van Delft & S. Balasubramanian*
    Angewandte Chemie 128:11310-11314 (2016) → full text

    • Selected as Hot Paper
    • Featured in Nature Biotechnology: Computing: Nothing more than DNA

16. Building proficient enzymes with foldamer prostheses.
    C. Mayer, M.M. Müller, S.H. Gellman, & D. Hilvert*
    Angewandte Chemie 126:7098-7101 (2016) → full text

    • Selected as Hot Paper

17. Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase.
    N. Preiswerk, T. Beck, J.D. Schulz, P. Milovnik, C. Mayer, J.B. Siegel, D. Baker & D. Hilvert*
    Proceedings of the National Academy of Sciences 111:8013-8018 (2014) → full text

18. A genetically encodable ligand for transfer hydrogenation.
    C. Mayer & D. Hilvert
    European Journal of Organic Chemistry 17:3427-3431 (2013) → full text

19. An artificial metalloenzyme for olefin metathesis.
    C. Mayer D.G. Gillingham, T.R. Ward & D. Hilvert*
    Chemical Communications 47:12068-12070 (2011) → full text

20. Synthesis of gamma-halogenated and long-chain ß-hydroxy-a-amino acids and 2-amino-1,3-diols using threonine aldolases.
    J. Steinreiber, K. Fresko, C. Mayer, C. Reisinger, M. Schürmann & H. Griengl*
    Tetrahedron 63:8088-8093 (2007) → full text