Our understanding of the complex, molecular processes in living organisms is at a level that seemed unimaginable only decades ago. Courtesy of the efforts that enabled this unprecedented insight, we have a powerful arsenal of tools at our disposal, which allows for probing and manipulating the structures and functions of the very building blocks that make up life. Access to this vast toolset makes chemists and biologists uniquely equipped to become engineers and reprogram the cellular machinery to facilitate man-made innovations. Pursuing this enticing concept, our research will focus on repurposing established genetic code expansion techniques for bioprocessing strategies that enable the production of value-added compounds from readily available precursors. Specifically, we will utilize orthogonal translation systems for drug discovery and to evaluate or tailor both enzymatic and non-enzymatic reactivities.
We will keep exapnding this section as our research progresses.